Predictions
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If the toxic-allergic hypothesis is correct the following predictions should be satisfied.
1.
Workers exposed to nephrotoxic chemicals should more often have symptoms
of glomerulonephritis than other people.
2. Patients with glomerulonephritis should have been exposed more often to nephrotoxic chemicals than other people.
3. Patients with glomerulonephritis and a decreased renal function should have been exposed more often than patients with glomerulonephritis and normal function.
4. Discontinuation of the exposure should improve renal function and the course of the disease.
5. The renal function and the course should be closer associated with the tubulointerstitial changes than with the glomerular changes.
6. Exposure of laboratory animals to nephrotoxic chemicals should produce glomerulonephritis with renal failure.
In the following I shall show that all of these predictions have been fulfilled.